Qexp-MDx Metabolism Related Genotyping Kit

Obesity has emerged as one of the most serious public health concerns in the twenty-first century. Someone keeps their shape well despite they guzzle down drink or food. Some people go on a diet and exercise but can‘t get rid of the weight they gain. Did you know that obesity is also related to genes in addition to acquired effects!

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Currently, common obesity genes include ADRB2, ADRB3, UCP1, PPAR?, GNB3, Sema3, and so on. Qexp-MDx Obesity Genotyping Kit is based on ADRB2, ADRB3, and UCP1 to analyze the risk of obesity.

Beta-2 adrenergic receptor, ADRB2
ADRB2 is a cell membrane-spanning beta-adrenergic receptor. It will couple with catecholamines to activate a series of downstream reactions that promote the decomposition of fat and carbohydrates. ADRB2 has a Guanine (G) mutation from Cytosine (C) at position 79 leading to a decreased efficiency of fat and carbohydrate metabolism and an increased risk of systemic obesity.

Beta-3 adrenergic receptor, ADRB3
The function of ADRB3 is co-related to the ADRB2. The difference is that ADRB3 is involved in intercellular signaling and is responsible for lipolysis and thermogenesis. ADRB3 has a Cytosine (C) mutation from Thymine (T) at position 190. It will lead to easy accumulation of fat and increase the risk of upper-body fat.

Thermogenin, UCP1
UCP1 is a mitochondrial carrier protein found in brown adipose tissue (BAT). UCP1 plays an important role in energy balance by consuming energy from food metabolism to generate heat. UCP1 has a Guanine (G) mutation from Adenine (A) at position 190. It leads to poorer thermogenesis effect and accumulate fat in the thighs and buttocks, resulting in lower-body obesity.

Qexp-MDx ADRB2 ADRB3 UCP1 Genotyping Kit
Catalog No.	Product	Unit
C903202-24 C903202-48	Qexp-MDx ADRB2/ADRB3/UCP1 Genotyping Kit	24 rxn 48 rxn