NGS Library Validation Using Automated Capillary Gel Electrophoresis _ American Laboratory
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NGS Library Validation Using Automated Capillary Gel Electrophoresis _ American Laboratory
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc.,1 and also in such clinical diagnostics applications as cancer screening and drug development.2 There are multiple commercial NGS platforms available, each incorporating unique operating principles (e.g., Roche 454FLX [454 Life Sciences, Branford, Conn.], Illumina Genome Sequencer3 [Illumina Inc., San Diego, Calif.] and Applied Biosystems/ABI SOLiD Sequencer [Foster City,Calif.]). No matter the platform, library preparation is the most critical step in the NGS workflow.