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The plastids may appear in different configurations such as loops with different degrees of winding, partial splits or threads, and tandem polymers. Common configuration categories are the covalently closed circular (ccc) form, the open circular (OC) form (also called "nicked form"), linear form (digested by restriction enzyme).
Restriction fragment length polymorphism (RFLP) is considered to be the simplest and earliest method to detect SNPs. SNP-RFLP makes use of the many different restriction endonucleases and their high affinity to unique and specific restriction sites.
On-Site Testing of Infectious Diseases: SARS-CoV-2
Background: Nucleic acid detection by RT-PCR method is one of the criteria approved by China FDA and US CDC for diagnosis of COVID-19, which requires highly trained personnel and can create inaccurate test results (for example, high false-negative rate and some false positive rate). Inaccurate results are caused by inadequate detection sensitivity of RT-PCR, low viral load in some patients, difficulty to collect samples from COVID-19 patients, insufficient sample loading during RT-PCR tests, and RNA degradation during the sample handling process.
Immunoassays are commonly used in biotechnology for the detection and quantification of host cell contaminants. The free-solution approach by CGE with fluorescence detection offers an exciting alternative to solid-phase immunoassay. It eliminates antigen immobilization and avoids many problems associated with solid phase. The methodology makes use of either a purified antigen labeled with stable fluorescent dye (i.e., FITC) or an affinity probe labeled with the dye (direct assay).
BiOptic Inc. introduces a cost-effective capillary gel-electrophoresis system for highly efficient, high speed, high throughput, Glycan analysis (N-Glycan). The Glycan Analyzer (GL1000) is a newly developed product that will significantly increase the pace at which glycoprotein research is performed in the lab, saving hours of preparation time and assuring accurate, consistent and economical results.
Degradation of RNA samples by RNase is a major cause of failure in the following experiments. The Qsep series bio-fragment analyzers can easily detect even slight degradation and display the results of RNA quality by gel-like profiling and Electropherogram.
Capillary gel electrophoresis using sodium dodecyl sulfate (CE-SDS) is used commercially to provide quantitative purity data for therapeutic protein characterization and release.
SNP genotyping is the measurement of genetic variations of single nucleotide polymorphisms (SNPs) between members of a species. Single-nucleotide polymorphisms (SNPs) are widespread genomic variations, which are associated with serious health disorders and drug resistance.
