Algorithm for optimized mRNA design improves stability and immunogenicity
2023-12-14
Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19(refs. 1–3), but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the vaccine products4. Increasing secondary structure lengthens mRNA half-life, which, together with optimal codons, improves protein expression5.
The Rapid Detection of Salmonella enterica, Listeria monocytogenes, and Staphylococcus aureus
2023-10-25
The PCR-CE method developed in this study may help monitor food safety in the future. It may also be extended to identify other foodborne pathogens across a wide range of food samples.
